This issue brief describes how telemedicine—the application of Information and Communications Technology (ICT) to provide health care services at a distance—is used to improve the health of California’s children, especially those who are low-income or living in medically underserved areas. The brief provides an overview of the benefits of telemedicine for children and families, health systems, and communities. It also outlines challenges to successful adoption of telemedicine and provides concrete recommendations for action.